Brief of the study: Ramzi Theory conducted by Dr. Saam Ramzi Ismail
“Ramzi’s Theory is using placenta/chorionic villi location as a marker for fetal gender detection at 6 weeks gestation was found to be highly reliable. This method correctly predicts the fetus gender in 97.2% of males and 97.5% of females early in the first trimester.”
Conflict of Interest Declaration
The author acknowledges no commercial affiliation or financial conflict of interest.
Advances in Knowledge
This study contributes to advances in knowledge by understanding the history of fetal gender and the ethical dilemma of choosing or detecting fetal gender at first trimester of the pregnancy.
It gives new prospective and method to detect fetal gender as early as possible to better manage some genetic disease which can be found in male or female fetuses. Thus, gives the parent the choice of what to do, and gives the gynaecologist’s and genetic counsellors the ability to manage, discuss and guide the parents to better management of the fetus.
Application to Patient Care
The application to patient care is in the knowledge gained by physicians, genetic counsellors and researchers that can be applied from the sonographers/sonoliogists ability to detect fetal gender as early as possible especially in families with genetic disorders that can be found in male or female fetuses. It will enhance the sonographer’s ability to correlate the finding with other genetic soft markers such as renal pyelectasis.
This study may help parents to decide and choose the type of medical management available in case of inherited genetic problem such as in X-linked genetic disorder.
This study might not be for all patients but definitely for those who want to know and prepare their life and finances and for those who have a genetic problem, which can inflect one gender than the other.
The aim of the Ramzi study is to determine the relationship between placental /chorionic villi laterality and fetal genders early in pregnancy using 2-D ultrasonography and colour flow Doppler.
Material and Method
This is a multi-center prospective cohort study of 5376 pregnant women that underwent ultrasonography from 1997 to 2007. Trans-vaginal sonograms were performed in 22% of the patients at 6 weeks gestation, and Trans-abdominal sonograms were used at 18-20 weeks gestation, at this time the fetal gender were confirmed in 98-99%. The fetal sex was confirmed 100% after delivery.
The study also addressed the bicornuate uteri with single pregnancy in relation to placenta / chorionic villi location. The result was tabulated according to gender and placenta / chorionic villi location. Bicornuate uteri with single fetus in different horns were studied and tabulated
Dramatic differences were detected in chorionic villi / placental location according to gender. 97.2% of the male fetuses had a chorionic villi/placenta location on the right side of the uterus whereas, 2.4% had a chorionic villi/placenta location to the left of the uterus.
On the other hand 97.5% of female fetuses had a placenta location to the left of the uterus whereas, 2.7% had their placenta location to the right side of the uterus. 127 cases were found to involve bicornuate uteri with single foetuses, most male fetuses were located in the right horn of the uterus and showed right placental laterality (70%).
Most female fetuses 59% on the other hand, were located in the left horn and showed left laterality (59%).Moreover, most of the males located in the left horn exhibited right laterality (89%). Also most females located in right horn exhibited left laterality (976.4%).
In addition this research indicated that there was a possible link between renal pyelectasis and placental location. This might be used as a genetic soft marker
Ramzi’s theory is using chorionic villi location as a marker for fetal gender detection at 6 weeks gestation. This was found to be highly reliable. This method correctly predicts the fetus gender in 97.2% of males and 97.5% of females early in the first trimester. And it might be helpful to use as a genetic soft marker in relation with fetal pyelectasis.
The full study on the Ramzi Theory can be found here Dr Ramzi Study